A second feature of our protein manipulation platform is our ability to
rationally design molecular glues to hit novel disease targets. Leveraging our
expertise in being able to precisely design a peptide that fits into the exact
contact points of a pathological protein, we have the major advantage of
exploiting the collective binding pocket that is formed by bringing two protein
interfaces together. By catenating two protein-binding peptides into a single
peptide molecular glue, that induce proximity between a pair of proteins, we can
strengthen and stabilize pre-existing protein-protein interactions, or create
de novo interactions, encouraging the binding between two proteins that
would not normally interact.
Many companies use small molecules as molecular glues. In spite of many
advantages of small molecules, it is still technically challenging to find a
selective protein-binding small molecule. Furthermore, finding a small molecule
as a molecular glue that selectively binds to two target proteins simultaneously
is even more technically challenging. In contrast, it is relatively easier and
faster to find peptides that selectively bind to target proteins.
Most molecular glues are designed to stick a target protein to a ligase that
triggers degradation. In our case, we design our molecular glues to stick any
two proteins together. Therefore, our peptide molecular glues not only can
trigger protein degradation, but also have many other applications, including,
but not limited to, protein stabilization and phosphorylation.
We are still in the early stages of this technology, as are many companies. However, by gluing any two proteins together, we are forging a new path for unlocking more undruggable proteins to be targeted.
Two protein-binding peptides catenated into a single peptide, inducing proximity between a pair of proteins. This strengthens and stabilizes pre-existing protein-protein interactions, or creates de novo interactions, encouraging the binding between two proteins that would not normally interact.
[ Protein-Protein Interference Blockade ] [ Molecular Glues ] [ CHAPTAC ] [ Intellectual Property ] [ Scientific Publications ]